Are High Ammonia Levels Making Your Brain Tired?

Are high ammonia levels making your brain tired?  Excess ammonia, or hyperammonemia, can be the cause of neurological and metabolic disorders.  Why do these levels rise and what can you do about it?

High Ammonia Levels - The Word Ammonia

 What Is Ammonia?

Ammonia is a colorless gas with a characteristic pungent odor. It is a compound of nitrogen and hydrogen. High-ammonia levels form from protein breakdown via intestinal bacteria. It is then converted into urea, and eliminated through the urine. Problems happen when levels of ammonia rise due to the liver’s inability to convert it to urea. Possible reasons and solutions are the subject of this article.

Watch This Short Video To Learn More:

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What Causes High Ammonia Levels In The Blood?

Ammonia build-up can result from a variety of factors. Liver damage, which includes both cirrhosis and hepatitis, are two likely culprits, as well as genetic SNPs. Heredity, toxicity due to viruses and chemicals, and poor food and lifestyle choices, such as drug and alcohol abuse, all play a role.

Signs of Ammonia Buildup

Elevated levels of ammonia decrease the production of cellular energy production or ATP. This results in numerous symptoms of ammonia accumulation. One may suspect elevated ammonia if any of these symptoms are present:

  • Unexplained lethargy and irritability
  • Loss of appetite
  • Muscle weakness
  • Vomiting and hyperventilation
  • Depression and mood disorders
  • Drowsiness, confusion, and disorientation due to the excess ammonia’s effects on the brain
  • Poor word retrieval and memory problems
  • Insomnia and poor concentration
  • Seizures
  • Changes in personality and behavior
  • Accelerated Aging

Liver Cirrhosis Disease

Cirrhosis- or scarring of the liver – is a complication of liver disease. It leads to abnormalities in liver structure and function.  Liver cells become injured, and can even die. Scar tissue then forms. This scarring is irreversible.

There can be many causes of cirrhosis. Unhealthy lifestyle habits,  alcohol consumption, and toxic fats in the diet, all contribute. Viruses and toxic metals play a role. Autoimmunity – where the body attacks itself – may be a factor, as well.

Symptoms can include fatigue, weakness, easy bruising, due to the decreased production of blood clotting factors, and loss of appetite. Itching and jaundiced skin may also occur. These symptoms are caused by the buildup of bilirubin in the blood. Bilirubin is formed by the break down of red blood cells. This condition, however, may show no obvious signs of liver disease.

[Read More: Can Non-Alcoholic Fatty Liver Disease Be Reversed?]

High Ammonia Levels - Fibrotic Liver

Hepatitis/Inflammation Of The Liver

Hepatitis – or inflammation of the liver – is an acute illness that does not progress to chronic liver disease. It could be autoimmune in nature or the result of medications and drugs, toxins, or alcohol. Viruses are responsible for approximately half of all cases of hepatitis. Hepatitis A, B, and C are the most common, although, there are more.  These viruses can cause acute hepatitis, with types B and C being implicated, in the chronic form.

The acute version of this condition includes fatigue and symptoms that are flu-like in nature, as well as dark urine, fever, jaundice, and pain in the upper right part of the abdomen. However, it can occur with minimal symptoms. Acute viral hepatitis is a common condition throughout the world, and there are vaccines to prevent it.

Typically, people recover within four to eight weeks even without treatment. Rarely does it result in liver failure. Since the symptoms of chronic hepatitis can be mild, diagnosis is often delayed. This condition does require treatment as it can lead to liver damage, cirrhosis, and even cancer.

CBS Genetic SNP

We’ve all heard the old adage that what is healthy for one person could be a poison for someone else. This is the case with sulphur. When most people hear this word, they think of detoxification, and the body’s most powerful antioxidant glutathione.

Certain genetic mutations, however, decrease a person’s ability to effectively metabolize and excrete ammonia, which is a byproduct of sulfur metabolism, and is toxic if levels accumulate in the bloodstream. The CBS genetic SNP (single nucleotide polymorphism) is one such mutation.

The CBS gene encodes an enzyme called cystathionine beta-synthase that aids in the conversion of homocysteine to cystathionine. It is part of the transsulfuration pathway in the methylation cycle. A defect in this enzyme can cause upregulation – which means it’s working too fast – causing ammonia levels to rise.

Dietary Restrictions

Dietary restrictions should be employed to stabilize this enzyme if it’s upregulated. Foods containing sulfur should be limited, including onions, garlic, cruciferous vegetables, and protein-rich dairy. Methylation precursors, such as, B12, folate, alpha lipoic acid, chlorella and spirulina should also be taken with caution.

Drinking tap water is problematic as chloramine (chlorine and ammonia) is added as a sterilizing agent. Water filters are not effective in removing this chemical, which means people are ingesting ammonia on a daily basis. For a person with a genetic susceptibility, this can have dire consequences. Genetics and the methylation cycle are hot topics today, and I will be writing more about the CBS mutation in future posts.

If you would like to learn more about CBS,  you can view the video below.

Tests to Determine High Levels of Ammonia

A blood sample is taken to assess liver function and ammonia levels. Ammonia is a nitrogen waste compound normally eliminated through the urine. Elevations can indicate possible liver and kidney dysfunction. These high levels can be potentially poisonous, and make you feel terrible! If left untreated, excess levels can result in delirium, confusion, and even seizures.

Elevated blood ammonia can affect a person at any age, and happens for a variety of reasons, and is no respecter of age or gender. It is fairly common in infants, in whom the disease can be related to a genetic condition call Reye’s Syndrome.

In adults, an elevated blood ammonia level may indicate kidney or liver damage or an underlying metabolic disease. In some cases, an elevated blood ammonia level will resolve on its own without treatment.

Natural Therapies to Reduce Ammonia Levels

Symptoms of elevated ammonia can be uncomfortable. The brain is especially susceptible to damage, and is not effective in buffering ammonia, which is inflammatory. It is also toxic to brain cells. Fortunately, there are natural therapies that help to reduce ammonia levels.

  • Avoiding excess protein keeps ammonia levels in check. Here’s a great Keto powder. Staying hydrated is also important for ammonia excretion.
  • Magnesium, the miracle mineral, is critical for at least 800 metabolic processes in the body. It’s a champ when it comes to ammonia toxicity as it helps to remove ammonia from the cells. It also stabilizes the blood brain barrier.

[Read More: What Is The Best Protein Powder On The Market?]? [Restructure Review]

[Read More: Facts About Magnesium You May Not Know]

  • Molydenum, manganese, carnitine, zinc and yucca are all helpful supplements.
  • Chlorophyll is a blood cleanser and is effective at neutralizing toxins such as ammonia. It is inexpensive, is a natural deodorizer, and has many other health benefits as well. Liver detoxification is also beneficial because less-than-optimal function leads to disturbed detoxification.

Get your ammonia levels tested here

Are High Ammonia Levels Making Your Brain Tired? - FDN Banner

Key Points

Ammonia toxicity is an interesting subject. It is also one that isn’t discussed frequently. It is important to be aware of the symptoms especially for those of us with genetic susceptibility. Awareness, along with changes in lifestyle and supplementation, can be instrumental in addressing this potentially dangerous condition.

Do you or someone you know suffer from elevated ammonia levels. Let me know in the comments:)




(1) NCBI: Ammonia metabolism in exercise and fatigue: a review

(2) Ammonia metabolism, the brain and fatigue; revisiting the link

(3) healthgrades: Elevated Blood Ammonia Level

(4) MedicinePlus: Loss of brain function – liver disease

(5) Institute of Basic Medical Sciences: When ammonia becomes toxic

(6) NCBI: Identifying the direct effects of ammonia on the brain

(7) NCBI: Ammonia Toxicity

(8) HealthEngine: Elevated Ammonia Levels: Cause & Symptoms


Disclaimer: This article is strictly for informational purposes only and is not intended to be medical advice.

4 thoughts on “Are High Ammonia Levels Making Your Brain Tired?”

  1. Great post! I have never thought I could get high ammonia levels from different food and drinks, as well as an unhealthy lifestyle until I came across your site and read the information you wrote. It was enlightening for me. 

    In the past few days, I have been thinking of changing my lifestyle and doing it gradually. Like you mentioned, liver damage could contribute to the increase of ammonia in the body, leading to various diseases and symptoms. From there, your post made me realize I have to do something for my health. Thank you very much. 

    • Thank you. Yes, most people aren’t aware that they could potentially have elevated ammonia levels. Optimal liver health is key in keeping these levels within range. It’s amazing how many processes in the body are dependent on good liver function. 

      Good for you for wanting to make changes in your lifestyle. Gradual changes are the ones that typically last. I wish you much success!

  2. This was a super useful post on ammonia and the effect it can have on your brain function and more. I had no idea that it could be so damaging, and read carefully to see what the symptoms are as well as how to prevent this condition that you have included.

    Some of the symptoms could be attributed to other causes, so if you have one or more, perhaps the best solution would be to see a doctor and get tested to see what is going on? It seems to me that might be better than trying to self-diagnose and treat this?

    The supplements you mention along with lifestyle changes likely would be enough to fend off this condition and are easily added as a part of the daily routine, but people need to be aware of the problem to make these changes. This article has gone a long way to help with that. Thanks. 

    I have bookmarked the website, you have a lot of useful advice and information…There needs to be more facts and research-based sites like this where someone like me can come to for advice and education, I will be passing the links onto others…

    • Thanks for reading my article Dave. I personally have experienced high levels of ammonia and I can attest to how miserable and intense the cognitive symptoms can be. I always have yucca on hand for those times. I happen to have the CBS SNP so I’m aware of the mechanism behind why this happens. 

      You can get genetic testing done through 23andMe for a reasonable price and it provides good information relative to high ammonia levels and other conditions. 

      Thanks so much for taking the time to comment and for passing the link to my site onto others!


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